Product Number |
OABB00919 |
Product Page |
www.avivasysbio.com/abcb1-antibody-middle-region-oabb00919.html |
Name |
ABCB1 Antibody - middle region (OABB00919) |
Molecular Weight |
141479 MW |
Clone |
Polyclonal |
Isotype |
Rabbit IgG |
NCBI Gene Id |
5243 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
500 ug/ml |
Gene Full Name |
ATP binding cassette subfamily B member 1 |
Description |
Rabbit IgG polyclonal antibody for Multidrug resistance protein 1(ABCB1) detection. Tested with IHC-P, IHC-F in Human;Mouse;Rat. |
Alias Symbols |
ABC20;ATP-binding cassette sub-family B member 1;ATP-binding cassette, sub-family B (MDR/TAP), member 1;ATP-dependent translocase ABCB1;CD243;CLCS;colchicin sensitivity;doxorubicin resistance;GP170;MDR1;multidrug resistance protein 1;p-170;P-glycoprotein 1;P-GP;PGY1;phospholipid transporter ABCB1. |
Product Format |
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Description of Target |
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
Reconstitution and Storage |
2°C to 8°C|-20°C |
Datasheets/Manuals |
Printable datasheet for ABCB1 Antibody - middle region (OABB00919) |
Specificity |
No cross reactivity with other proteins. |
Additional Information |
Notes: Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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Additional Information |
Background: P-GP, also called ABCB1 or PGY1, is a glycoprotein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily. It is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent drug efflux pump with broad substrate specificity. P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the bloodbrain barrier. |
Application Info |
Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human, Mouse, Rat: By Heat Immunohistochemistry (Frozen Section): 0.5-1 ug/ml: Mouse, Rat |
Immunogen |
Polypeptide |
Storage Buffer |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Uniprot ID |
P08183 |
Protein Name |
Multidrug resistance protein 1 |
Purification |
Affinity Purified |
Tested Species Reactivity |
Human, Mouse, Rat |
Gene Symbol |
ABCB1 |
Predicted Species Reactivity |
Human|Mouse|Rat |
Application |
Immunohistochemistry |
Image 1 | Mouse Intestine Tissue
| Anti-P Glycoprotein Picoband antibody IHC(F): Mouse Intestine Tissue |
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Image 2 | Rat Kidney Tissue
| Anti-P Glycoprotein Picoband antibody IHC(F): Rat Kidney Tissue |
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Image 3 | Human Lung Cancer Tissue
| Anti-P Glycoprotein Picoband antibody IHC(P): Human Lung Cancer Tissue |
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Image 4 | Mouse Kidney Tissue
| Anti-P Glycoprotein Picoband antibody IHC(P): Mouse Kidney Tissue |
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Image 5 | Rat Kidney Tissue
| Anti-P Glycoprotein Picoband antibody IHC(P): Rat Kidney Tissue |
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