CDK1 Antibody (Phospho-Thr14) (OAAN02724)

Data Sheet
 
Product Number OAAN02724
Product Page www.avivasysbio.com/cdk1-antibody-phospho-thr14-oaan02724.html
Name CDK1 Antibody (Phospho-Thr14) (OAAN02724)
Molecular Weight 34 kDa
Isotype IgG
Conjugation Unconjugated
NCBI Gene Id 983
Host Rabbit
Clonality Polyclonal
Gene Full Name cyclin-dependent kinase 1
Description
Alias Symbols CDC2, CDC28A, P34CDC2
Product Format Liquid
Description of Target The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Reconstitution and Storage Store at -20C. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CDK1 (OAAN02724)
Application Info WB: 1:500 - 1:1,000. IF: 1:50 - 1:100
Immunogen A phospho-Serpecific peptide corresponding-Thro residues-Serurrounding-Thr14 of human CDK1
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Uniprot ID P06493
Protein Name Cyclin-dependent kinase 1
Publications

The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis. Cell Prolif. 53, e12769 (2020). 32003502

The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality. Aging (Albany NY). 11, 1110-1128 (2019). 30786262

Protein Accession # NP_001777.1
Purification Affinity purified against immunogen
Nucleotide Accession # NM_001786.4
Target Post-Translational Modification Phospho-Thr14
Preservative 0.02% Sodium Azide
Gene Symbol CDK1
Predicted Species Reactivity Human, Mouse, Rat
Application WB, IF
Image 1
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using Phospho-CDK1-T14 antibody.
Image 2
MCF7 Cells,Multiple Cell Lines
Immunofluorescence analysis of MCF7 cell using Phospho-CDK1-T14 antibody. Blue: DAPI for nuclear staining.
 

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