Product Number |
OAAN02724 |
Product Page |
www.avivasysbio.com/cdk1-antibody-phospho-thr14-oaan02724.html |
Name |
CDK1 Antibody (Phospho-Thr14) (OAAN02724) |
Molecular Weight |
34 kDa |
Isotype |
IgG |
Conjugation |
Unconjugated |
NCBI Gene Id |
983 |
Host |
Rabbit |
Clonality |
Polyclonal |
Gene Full Name |
cyclin-dependent kinase 1 |
Description |
|
Alias Symbols |
CDC2, CDC28A, P34CDC2 |
Product Format |
Liquid |
Description of Target |
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Reconstitution and Storage |
Store at -20C. Avoid repeated freeze/thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CDK1 (OAAN02724) |
Application Info |
WB: 1:500 - 1:1,000. IF: 1:50 - 1:100 |
Immunogen |
A phospho-Serpecific peptide corresponding-Thro residues-Serurrounding-Thr14 of human CDK1 |
Storage Buffer |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Uniprot ID |
P06493 |
Protein Name |
Cyclin-dependent kinase 1 |
Publications |
The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis. Cell Prolif. 53, e12769 (2020). 32003502
The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality. Aging (Albany NY). 11, 1110-1128 (2019). 30786262 |
Protein Accession # |
NP_001777.1 |
Purification |
Affinity purified against immunogen |
Nucleotide Accession # |
NM_001786.4 |
Target Post-Translational Modification |
Phospho-Thr14 |
Preservative |
0.02% Sodium Azide |
Gene Symbol |
CDK1 |
Predicted Species Reactivity |
Human, Mouse, Rat |
Application |
WB, IF |
Image 1 | Multiple Cell Lines
| Western blot analysis of extracts of various cell lines, using Phospho-CDK1-T14 antibody. |
| Image 2 | MCF7 Cells,Multiple Cell Lines
| Immunofluorescence analysis of MCF7 cell using Phospho-CDK1-T14 antibody. Blue: DAPI for nuclear staining. |
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