| Product Number |
OAAN00021 |
| Product Page |
www.avivasysbio.com/bcl2l1-antibody-oaan00021.html |
| Name |
BCL2L1 Antibody (OAAN00021) |
| Molecular Weight |
26 kDa |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
598 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
BCL2 like 1 |
| Alias Symbols |
BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S |
| Peptide Sequence |
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREV |
| Product Format |
Liquid PBS with 0.01% Thimerosal and 50% glycerol (pH 7.3) |
| Description of Target |
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
| Reconstitution and Storage |
Store at -20°C. Avoid repeated freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-BCL2L1 (OAAN00021) |
| Additional Information |
Cellular Location: Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Mitochondrion inner membrane, Mitochondrion matrix, Mitochondrion outer membrane, Nucleus membrane, Single-pass membrane protein, centrosome, cytoskeleton, cytosol, microtubule organizing center, secretory vesicle, synaptic vesicle membrane.
Positive Samples: OVCAR3, Rat lung, Rat spleen |
| Application Info |
WB: 1:500~1000
IHC: 1:50~200
IF/ICC: 1:50~200
IP: 1:50~100 |
| Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human Bcl-XL (NP_612815.1). |
| Uniprot ID |
Q07817 |
| Protein Name |
Bcl-2-like protein 1 |
| Protein Accession # |
NP_001182.1 |
| Purification |
Affinity purified against immunogen |
| Nucleotide Accession # |
NM_001191.3 |
| Gene Symbol |
BCL2L1 |
| Predicted Species Reactivity |
Human, Mouse, Rat |
| Application |
WB, IHC, IF, IP |
| Image 1 | Multiple Cell Types
 | Western blot analysis of extracts of various cells, using BCL2L1 antibody. |
| | Image 2 | Colon Cancer,Human Kidney,Multiple Cell Types
 | Immunohistochemistry of paraffin-embedded colon cancer using BCL2L1 antibody. |
| | Image 3 | Human Kidney
 | Immunohistochemistry of paraffin-embedded human kidney using BCL2L1 antibody at dilution of 1:200 (x400 lens) |
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