| Product Number |
OAAJ07724 |
| Product Page |
www.avivasysbio.com/ddx5-antibody-oaaj07724.html |
| Name |
DDX5 Antibody (OAAJ07724) |
| Molecular Weight |
69 kDa |
| NCBI Gene Id |
1655 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/mL |
| Alias Symbols |
p68, HLR1, G17P1, HUMP68 |
| Product Format |
Liquid |
| Description of Target |
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. |
| Reconstitution and Storage |
Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-DDX5 (OAAJ07724) antibody |
| Immunogen |
Recombinant protein of human DDX5 |
| Uniprot ID |
P17844 |
| Protein Name |
Probable ATP-dependent RNA helicase DDX5 |
| Protein Accession # |
NP_001307524 |
| Purification |
Immunogen affinity chromatography |
| Nucleotide Accession # |
NM_001320595 |
| Gene Symbol |
DDX5 |
| Predicted Species Reactivity |
Human, Mouse, Rat |
| Application |
WB, IHC |
| Image 1 | various cell lines
 | Western blot analysis of extracts of various celllines, using RAD51 antibody. |
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