Product Number |
OAAJ06912 |
Product Page |
www.avivasysbio.com/pick1-antibody-oaaj06912.html |
Name |
PICK1 Antibody (OAAJ06912) |
Molecular Weight |
47 kDa |
NCBI Gene Id |
9463 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Alias Symbols |
PICK, PRKCABP |
Product Format |
Liquid |
Description of Target |
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
Reconstitution and Storage |
Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-PICK1 (OAAJ06912) antibody |
Immunogen |
A synthetic peptideof human PICK1 |
Uniprot ID |
Q9NRD5 |
Protein Name |
PRKCA-binding protein |
Protein Accession # |
NP_001034672 |
Purification |
Immunogen affinity chromatography |
Nucleotide Accession # |
NM_001039583 |
Gene Symbol |
PICK1 |
Predicted Species Reactivity |
Human, Mouse, Rat |
Application |
WB, IHC |
Image 1 | various cell lines
| Western blot analysis of extracts of variouscell lines, using PICK1 antibody. |
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