| Product Number |
OAAJ02517 |
| Product Page |
www.avivasysbio.com/rps6kb1-antibody-phospho-thr389-412-oaaj02517.html |
| Name |
RPS6KB1 Antibody (Phospho-Thr389/412) (OAAJ02517) |
| Molecular Weight |
70 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
6198 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
| Alias Symbols |
S6K, PS6K, S6K1, STK14A, p70-S6K, p70 S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha |
| Product Format |
Liquid. PBS pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Description of Target |
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. |
| Reconstitution and Storage |
Store at -20C. Stable for 12 months from date of receipt. |
| Datasheets/Manuals |
Printable datasheet for anti-RPS6KB1 (OAAJ02517) antibody |
| Specificity |
Phospho-p70 S6 Kinase (Thr389/412) antibody detects endogenous levels of p70 S6 Kinase only when phosphorylated at Threonine 389/412 |
| Additional Information |
Subcellular Location: Cytoplasm; Nucleus. Cytoplasm and Cell junction > synapse > synaptosome. Mitochondrion outer membrane.
Tissue Specificity: Widely expressed.
Function: The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop.The TOS (TOR signaling) motif is essential for activation by mTORC1.Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. |
| Application Info |
WB: 1:500~2000
IHC: 1:50~200
IF/ICC: 1:100~500
|
| Immunogen |
A synthesized peptide derived from human p70 S6 Kinase around the phosphorylation site of Threonine 389/412 |
| Uniprot ID |
P23443 |
| Purification |
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Gene Symbol |
RPS6KB1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Pig |
| Application |
WB, IHC, IF, ICC |
| Image 1 | Jurkat whole cell lysates
 | Western blot analysis of p70 S6 Kinase phosphorylation expression in Insulin treated Jurkat whole cell lysates. The lane on the left is treated with the antigen-specific peptide. |
|
|
