| Product Number |
OAAJ02077 |
| Product Page |
www.avivasysbio.com/bcar3-antibody-oaaj02077.html |
| Name |
BCAR3 Antibody (OAAJ02077) |
| Molecular Weight |
92 kDa |
| NCBI Gene Id |
8412 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
breast cancer anti-estrogen resistance 3 |
| Alias Symbols |
MIG7, NSP2, AND-34, SH2D3B |
| Product Format |
Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Description of Target |
a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described. |
| Reconstitution and Storage |
Store at -20C. Stable for 12 months from date of receipt. |
| Datasheets/Manuals |
Printable datasheet for anti-BCAR3 (OAAJ02077) antibody |
| Specificity |
BCAR3 antibody detects endogenous levels of BCAR3 |
| Application Info |
WB: 1:500-1:2000 IHC: 1:50-1:200 |
| Immunogen |
A synthesized peptide derived from human BCAR3 |
| Uniprot ID |
O75815 |
| Purification |
Immunogen affinity purified |
| Gene Symbol |
BCAR3 |
| Predicted Species Reactivity |
Human |
| Application |
WB, IHC |
| Image 1 | HeLa cell lysate
 | Western blot analysis on HeLa cell lysate using BCAR3 Antibody |
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