| Product Number |
OAAH00031 |
| Product Page |
www.avivasysbio.com/casp3-antibody-oaah00031.html |
| Name |
CASP3 Antibody (OAAH00031) |
| Protein Size (# AA) |
277 amino acids |
| Molecular Weight |
32 kDa |
| Isotype |
Mouse IgG |
| NCBI Gene Id |
836 |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Source |
Mouse mAb |
| Gene Full Name |
Caspase-3 |
| Alias Symbols |
CPP32, SCA-1, CPP32B |
| Reference |
1.Benhar, M., Forrester, M. T., Hess, D. T., Science 320: 1050-1054, 2008.
2.Gervais, F. G., Xu, D., Robertson, G. S., Cell 97: 395-406, 1999.
3.Lakhani, S. A., Masud, A., Kuida, K., Science 311: 847-851, 2006.
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| Description of Target |
This gene is a member of the cysteine-aspartic acid protease (caspase) family. Alternative splicing of this gene results in two transcript variants that encode the same protein. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases-3 exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspases-3 cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10 |
| Reconstitution and Storage |
Store the product at -20C. Stable for one year from the date of shipment. |
| Datasheets/Manuals |
Printable datasheet for anti-CASP3 (OAAH00031) antibody |
| Specificity |
Caspase-3 Mouse monoclonal antibody detects endogenous levels of Caspase-3 protein. |
| Additional Information |
Localization: Cytoplasm |
| Application Info |
WB: 1:500-1:1000 |
| Immunogen |
This Aviva monoclonal antibody is produced by immunizing mice with recombinant polypeptide (Aviva SEAL mAb technology) corresponding to surface multi-epitopes of human Caspase-3. |
| Uniprot ID |
P42574 |
| Protein Name |
Caspase-3 |
| Protein Accession # |
NP_004337.2; NP_116786.1 |
| Nucleotide Accession # |
NM_004346.3; NM_032991.2 |
| Gene Symbol |
CASP3 |
| Predicted Species Reactivity |
Human |
| Application |
WB, IF, IHC |
| Image 1 | 293T, F9, NIH3T3
 | Endogenous Caspase-3 detected in 293T(Lane1), F9(Lane2), NIH3T3(Lane3) cell lysates
Primary antibody: 1:500 |
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