| Product Number |
OAAF05316 |
| Product Page |
www.avivasysbio.com/casp6-cleaved-asp179-antibody-oaaf05316.html |
| Name |
CASP6 Antibody (Cleaved-Asp179) (OAAF05316) |
| Molecular Weight |
20 and 35 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
839 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/mL |
| Gene Full Name |
caspase 6 |
| Description |
|
| Alias Symbols |
apoptotic protease MCH-2;caspase 6, apoptosis-related cysteine peptidase;caspase 6, apoptosis-related cysteine protease;caspase-6;MCH2. |
| Product Format |
Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| Description of Target |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
| Reconstitution and Storage |
Store at -20°C for 1 year. |
| Datasheets/Manuals |
Printable datasheet for CASP6 Antibody (Cleaved-Asp179) (OAAF05316) |
| Specificity |
Caspase 6 (cleaved-Asp179) antibody detects endogenous levels of fragment of activated Caspase 6 resulting from cleavage adjacent to Asp179. |
| Application Info |
WB: 1/500 - 1/2000
IHC: 1/100 - 1/300
ELISA: 1/40000 |
| Immunogen |
The antiserum was produced against synthesized peptide derived from human Caspase 6. Loc: 130-179aa |
| Uniprot ID |
P55212 |
| Protein Name |
Caspase-6 |
| Publications |
Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding. J. Neurosci. Methods. 282, 20-33 (2017). 28267565
Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 61, 44531 (2018). 29031088 |
| Protein Accession # |
NP_001217.2 |
| Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Target Post-Translational Modification |
Cleaved |
| Gene Symbol |
CASP6 |
| Predicted Species Reactivity |
Human|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | 293
 | Western blot analysis of lysates from 293 cells, treated with Etoposide 25uM 60', using Caspase 6 (Cleaved-Asp179) Antibody. The lane on the right is blocked with the synthesized peptide. |
|
| Image 2 | human lung carcinoma
 | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp179) Antibody. The picture on the right is blocked with the synthesized peptide. |
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