Product Number |
OAAF05314 |
Product Page |
www.avivasysbio.com/casp3-cleaved-asp175-antibody-oaaf05314.html |
Name |
CASP3 (Cleaved-Asp175) Antibody (OAAF05314) |
Molecular Weight |
20 kDa |
Isotype |
IgG |
NCBI Gene Id |
836 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1 mg/ml |
Gene Full Name |
caspase 3 |
Alias Symbols |
apopain;CASP-3;caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;caspase-3;CPP32;CPP-32;CPP32B;cysteine protease CPP32;PARP cleavage protease;procaspase3;protein Yama;SCA-1;SREBP cleavage activity 1. |
Product Format |
Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol |
Reference |
John K. Jain, Biol Reprod, Aug 2005; 73: 382 - 388.
C.S. Thota, Biol Reprod, Dec 2005; 73: 1191 - 1198.
Koichi Ushizawa, Biol Reprod, Feb 2006; 74: 344 - 351.
ULRICH STEIDL, Ann. N.Y. Acad. Sci., Jun 2005; 1044: 94 - 108. |
Description of Target |
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. |
Reconstitution and Storage |
-20°C |
Datasheets/Manuals |
Printable datasheet for CASP3 (Cleaved-Asp175) Antibody (OAAF05314) |
Specificity |
Caspase 3 (Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175. |
Application Info |
WB: 1:500~1:1,000
IHC: 1:50~1:100
ELISA: 1:20,000
Optimal dilutions should be determined by the end user. |
Immunogen |
The antiserum was produced against synthesized peptide derived from human Caspase 3. |
Uniprot ID |
P42574 |
Protein Name |
Caspase-3 |
Protein Accession # |
NP_004337.2 |
Purification |
The antibody was purified from rabbit antiserum by affinity chromatography using immunogen. |
Gene Symbol |
CASP3 |
Predicted Species Reactivity |
Human|Mouse|Rat |
Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot |
Image 1 | |
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