CASP3 (Cleaved-Asp175) Antibody (OAAF05314)

Data Sheet
 
Product Number OAAF05314
Product Page www.avivasysbio.com/casp3-cleaved-asp175-antibody-oaaf05314.html
Name CASP3 (Cleaved-Asp175) Antibody (OAAF05314)
Molecular Weight 20 kDa
Isotype IgG
NCBI Gene Id 836
Host Rabbit
Clonality Polyclonal
Concentration 1 mg/ml
Gene Full Name caspase 3
Alias Symbols apopain;CASP-3;caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;caspase-3;CPP32;CPP-32;CPP32B;cysteine protease CPP32;PARP cleavage protease;procaspase3;protein Yama;SCA-1;SREBP cleavage activity 1.
Product Format Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Reference John K. Jain, Biol Reprod, Aug 2005; 73: 382 - 388.
C.S. Thota, Biol Reprod, Dec 2005; 73: 1191 - 1198.
Koichi Ushizawa, Biol Reprod, Feb 2006; 74: 344 - 351.
ULRICH STEIDL, Ann. N.Y. Acad. Sci., Jun 2005; 1044: 94 - 108.
Description of Target Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Reconstitution and Storage -20°C
Datasheets/Manuals Printable datasheet for CASP3 (Cleaved-Asp175) Antibody (OAAF05314)
Specificity Caspase 3 (Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
Application Info WB: 1:500~1:1,000
IHC: 1:50~1:100
ELISA: 1:20,000
Optimal dilutions should be determined by the end user.
Immunogen The antiserum was produced against synthesized peptide derived from human Caspase 3.
Uniprot ID P42574
Protein Name Caspase-3
Protein Accession # NP_004337.2
Purification The antibody was purified from rabbit antiserum by affinity chromatography using immunogen.
Gene Symbol CASP3
Predicted Species Reactivity Human|Mouse|Rat
Application Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
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