Product Number |
OAAF04822 |
Product Page |
www.avivasysbio.com/fzd9-antibody-oaaf04822.html |
Name |
FZD9 Antibody (OAAF04822) |
Molecular Weight |
64 kDa |
Isotype |
IgG |
NCBI Gene Id |
8326 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1 mg/ml |
Gene Full Name |
frizzled class receptor 9 |
Alias Symbols |
CD349;frizzled 9, seven transmembrane spanning receptor;frizzled family receptor 9;frizzled homolog 9;frizzled-9;fz-9;FZD3;fzE6;hFz9. |
Product Format |
Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Reference |
Wang Y.-K., Hum. Mol. Genet. 6:465-472(1997). Hillier L.W., Nature 424:157-164(2003). Tanaka S., Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998). |
Description of Target |
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). |
Reconstitution and Storage |
-20°C |
Datasheets/Manuals |
Printable datasheet for FZD9 Antibody (OAAF04822) |
Specificity |
FZD9 antibody detects endogenous levels of total FZD9 protein. |
Application Info |
WB: 1:500~1000 IF: 1:100~500 ELISA: 1:20000 |
Immunogen |
The antiserum was produced against synthesized peptide derived from human FZD9. |
Dilution |
The optimal working dilution should be determined by the end user. |
Uniprot ID |
O00144 |
Protein Name |
Frizzled-9 |
Protein Accession # |
NP_003499.1 |
Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
Gene Symbol |
FZD9 |
Predicted Species Reactivity |
Human|Monkey|Mouse |
Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot |
Image 1 | A549 cells
| Immunofluorescence analysis of A549 cells, using FZD9 Antibody. The picture on the right is blocked with the synthesized peptide. |
| Image 2 | HuvEc/COLO/COS cells
| Western blot analysis of extracts from HuvEc/COLO/COS cells, using FZD9 Antibody. The lane on the right is blocked with the synthesized peptide. |
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