FZD9 Antibody (OAAF04822)

Data Sheet
 
Product Number OAAF04822
Product Page www.avivasysbio.com/fzd9-antibody-oaaf04822.html
Name FZD9 Antibody (OAAF04822)
Molecular Weight 64 kDa
Isotype IgG
NCBI Gene Id 8326
Host Rabbit
Clonality Polyclonal
Concentration 1 mg/ml
Gene Full Name frizzled class receptor 9
Alias Symbols CD349;frizzled 9, seven transmembrane spanning receptor;frizzled family receptor 9;frizzled homolog 9;frizzled-9;fz-9;FZD3;fzE6;hFz9.
Product Format Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reference Wang Y.-K., Hum. Mol. Genet. 6:465-472(1997).
Hillier L.W., Nature 424:157-164(2003).
Tanaka S., Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998).
Description of Target Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).
Reconstitution and Storage -20°C
Datasheets/Manuals Printable datasheet for FZD9 Antibody (OAAF04822)
Specificity FZD9 antibody detects endogenous levels of total FZD9 protein.
Application Info WB: 1:500~1000
IF: 1:100~500
ELISA: 1:20000
Immunogen The antiserum was produced against synthesized peptide derived from human FZD9.
Dilution The optimal working dilution should be determined by the end user.
Uniprot ID O00144
Protein Name Frizzled-9
Protein Accession # NP_003499.1
Purification The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Gene Symbol FZD9
Predicted Species Reactivity Human|Monkey|Mouse
Application Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
Image 1
A549 cells
Immunofluorescence analysis of A549 cells, using FZD9 Antibody. The picture on the right is blocked with the synthesized peptide.
Image 2
HuvEc/COLO/COS cells
Western blot analysis of extracts from HuvEc/COLO/COS cells, using FZD9 Antibody. The lane on the right is blocked with the synthesized peptide.
 

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