| Product Number |
OAAF04786 |
| Product Page |
www.avivasysbio.com/crhr1-antibody-oaaf04786.html |
| Name |
CRHR1 Antibody (OAAF04786) |
| Molecular Weight |
50 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
104909134|1394 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
corticotropin releasing hormone receptor 1|LINC02210-CRHR1 readthrough |
| Alias Symbols |
corticotropin-releasing factor receptor 1;corticotropin-releasing factor type 1 receptor;Corticotropin-releasing hormone receptor 1;CRF1;CRF-R;CRFR1;CRFR-1;CRF-R1;CRF-R-1;CRHR;CRH-R1;CRH-R-1;CRHR1-IT1-CRHR1;CRHR1-IT1-CRHR1 protein;CRHR1-IT1-CRHR1 readthrough;CRHR1L;MGC57346-CRHR1;seven transmembrane helix receptor. |
| Product Format |
Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Reference |
Chen R., Proc. Natl. Acad. Sci. U.S.A. 90:8967-8971(1993).
Vita N., FEBS Lett. 335:1-5(1993).
Sakai K., Gene 219:125-130(1998). |
| Description of Target |
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for CRHR1 Antibody (OAAF04786) |
| Specificity |
CRHR1 antibody detects endogenous levels of total CRHR1 protein. |
| Application Info |
WB 1:500~1000
IF 1:100~500
ELISA1:5000 |
| Immunogen |
The antiserum was produced against synthesized peptide derived from human CRHR1. |
| Uniprot ID |
P34998 |
| Protein Name |
Corticotropin-releasing factor receptor 1 |
| Protein Accession # |
NP_001138618.1 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
CRHR1|LINC02210-CRHR1 |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | HT-29/LOVO cells
 | Western blot analysis of extracts from HT-29/LOVO cells, using CRHR1 Antibody. The lane on the right is treated with the synthesized peptide. |
| | Image 2 | MCF7 cells
 | Immunofluorescence analysis of MCF7 cells, using CRHR1 Antibody. The picture on the right is treated with the synthesized peptide. |
|
|
