| Product Number |
OAAF04109 |
| Product Page |
www.avivasysbio.com/chml-antibody-oaaf04109.html |
| Name |
CHML Antibody (OAAF04109) |
| Molecular Weight |
74 kDa |
| NCBI Gene Id |
1122 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
CHM like Rab escort protein |
| Alias Symbols |
CHM like Rab escort protein 2;choroideraemia-like protein;choroideremia-like (Rab escort protein 2);choroideremia-like protein;Rab escort protein 2;rab proteins geranylgeranyltransferase component A 2;REP2. |
| Product Format |
Liquid |
| Reference |
Cremers F.P.M., Hum. Mol. Genet. 1:71-75(1992).
Kasper G., Gene 295:27-32(2002).
Ota T. Nat. Genet. 36:40-45(2004) |
| Description of Target |
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for CHML Antibody (OAAF04109) |
| Specificity |
CHML antibody detects endogenous levels of total CHML protein. |
| Application Info |
WB: 1:500~1:3000; IHC: 1:50~1:100; ELISA: 1:1000 |
| Immunogen |
The antiserum was produced against synthesized peptide derived from human CHML. |
| Dilution |
The optimal working dilution should be determined by the end user. |
| Formulation |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot ID |
P26374 |
| Protein Name |
Rab proteins geranylgeranyltransferase component A 2 |
| Publications |
Li, J. et al. Proteomic-based approach for biomarkers discovery in early detection of invasive urothelial carcinoma. Proteomics. Clin. Appl. 2, 78-89 (2008). 21136781 |
| Protein Accession # |
NP_001812.2 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
CHML |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | human lung carcinoma tissue
 | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CHML Antibody. The picture on the right is treated with the synthesized peptide. |
|
| Image 2 | COLO cells
 | Western blot analysis of extracts from COLO cells, using CHML Antibody. The lane on the right is treated with the synthesized peptide. |
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