CLASP1 Antibody (OAAF03506)

Data Sheet
 
Product Number OAAF03506
Product Page www.avivasysbio.com/clasp1-antibody-oaaf03506.html
Name CLASP1 Antibody (OAAF03506)
Molecular Weight 169 kDa
NCBI Gene Id 23332
Host Rabbit
Clonality Polyclonal
Gene Full Name cytoplasmic linker associated protein 1
Alias Symbols CLIP-associating protein 1;Cytoplasmic linker-associated protein 1;MAST1;multiple asters 1;multiple asters homolog 1;protein Orbit homolog 1.
Product Format Liquid
Reference Maiato H., Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Hillier L.W., Nature 434:724-731(2005).
Akhmanova A., Cell 104:923-935(2001).
Description of Target Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Reconstitution and Storage -20°C
Datasheets/Manuals Printable datasheet for CLASP1 Antibody (OAAF03506)
Specificity CLASP1 antibody detects endogenous levels of total CLASP1 protein.
Application Info WB: 1:500~1:3000; IHC: 1:50~1:100
Immunogen The antiserum was produced against synthesized peptide derived from human CLASP1.
Dilution The optimal working dilution should be determined by the end user.
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Uniprot ID Q7Z460
Protein Name CLIP-associating protein 1
Protein Accession # NP_001135745.1
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Gene Symbol CLASP1
Predicted Species Reactivity Human|Mouse
Application Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Image 1
Jurkat cells
Western blot analysis of extracts from Jurkat cells, using CLASP1 Antibody. The lane on the right is treated with the synthesized peptide.
Image 2
human testis tissue
Immunohistochemistry analysis of paraffin-embedded human testis tissue, using CLASP1 Antibody. The picture on the right is treated with the synthesized peptide.
 

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