| Product Number |
OAAF03292 |
| Product Page |
www.avivasysbio.com/apool-antibody-oaaf03292.html |
| Name |
APOOL Antibody (OAAF03292) |
| Molecular Weight |
29 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
139322 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
apolipoprotein O like |
| Description |
|
| Alias Symbols |
AAIR8193;Apolipoprotein O-like;CXorf33;FAM121A;family with sequence similarity 121A;Mic27;MICOS complex subunit MIC27;MICOS27;mitochondrial contact site and cristae organizing system subunit 27;Protein FAM121A;UNQ8193. |
| Product Format |
Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Reference |
Clark H.F., Genome Res. 13:2265-2270(2003).
Ross M.T., Nature 434:325-337(2005).
The MGC Project Team; Genome Res. 14:2121-2127(2004). |
| Description of Target |
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979). |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for APOOL Antibody (OAAF03292) |
| Specificity |
APOOL antibody detects endogenous levels of total APOOL protein. |
| Application Info |
WB 1:500~1000
ELISA 1:40000
|
| Immunogen |
The antiserum was produced against synthesized peptide derived from human APOOL. |
| Dilution |
The optimal working dilution should be determined by the end user. |
| Uniprot ID |
Q6UXV4 |
| Protein Name |
MICOS complex subunit MIC27 |
| Publications |
Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv. 3, e1700677 (2017). 28835921
QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Elife. 4, (2015). 25997101
QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease. Elife. 5, (2016). 27623147 |
| Protein Accession # |
NP_940852.3 |
| Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
| Gene Symbol |
APOOL |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Western blot |
| Image 1 | COLO/NIH-3T3 cells
 | Western blot analysis of extracts from COLO/NIH-3T3 cells, using APOOL Antibody. The lane on the right is blocked with the synthesized peptide. |
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