| Product Number |
OAAF02871 |
| Product Page |
www.avivasysbio.com/ccrl1-antibody-oaaf02871.html |
| Name |
CCRL1 Antibody (OAAF02871) |
| Molecular Weight |
39 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
51554 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
atypical chemokine receptor 4 |
| Alias Symbols |
atypical chemokine receptor 4;C-C chemokine receptor type 11;CC chemokine receptor-like 1;C-C CKR-11;CCBP2;CC-CKR-11;CCR10;CCR11;CCR-11;CCRL1;CCX CKR;CCX-CKR;chemocentryx chemokine receptor;chemokine (C-C motif) receptor-like 1;chemokine, cc motif, receptor-like protein 1;CKR-11;orphan seven-transmembrane receptor, chemokine related;PPR1;VSHK1. |
| Product Format |
Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Reference |
Khoja H., Gene 246:229-238(2000).
Schweickart V.L., J. Biol. Chem. 275:9550-9556(2000).
Gosling J., J. Immunol. 164:2851-2856(2000). |
| Description of Target |
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for CCRL1 Antibody (OAAF02871) |
| Specificity |
CCRL1 antibody detects endogenous levels of total CCRL1 protein. |
| Application Info |
WB: 1:500~1000
IF: 1:100~500
ELISA: 1:60000 |
| Immunogen |
The antiserum was produced against synthesized peptide derived from human CCRL1. |
| Dilution |
The optimal working dilution should be determined by the end user. |
| Uniprot ID |
Q9NPB9 |
| Protein Name |
Atypical chemokine receptor 4 |
| Protein Accession # |
NP_057641.1 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
ACKR4 |
| Predicted Species Reactivity |
Human|Mouse |
| Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot |
| Image 1 | HepG2 cells
 | Western blot analysis of extracts from HepG2 cells, using CCRL1 Antibody. The lane on the right is treated with the synthesized peptide. |
|
| Image 2 | MCF7 cells
 | Immunofluorescence analysis of MCF7 cells, using CCRL1 Antibody. The picture on the right is treated with the synthesized peptide. |
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