| Product Number |
OAAF01932 |
| Product Page |
www.avivasysbio.com/sncb-antibody-oaaf01932.html |
| Name |
SNCB Antibody (OAAF01932) |
| Molecular Weight |
14 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
6620 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
synuclein beta |
| Alias Symbols |
beta-synuclein;I(2)-synuclein. |
| Product Format |
Liquid containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| Reference |
Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 - 3011.
Makoto Hashimoto, J. Biol. Chem., May 2004; 279: 23622 - 23629.
Cristine Alves da Costa, J. Biol. Chem., Sep 2003; 278: 37330 - 37335.
Heather Snyder, J. Biol. Chem., Mar 2005; 280: 75 |
| Description of Target |
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for SNCB Antibody (OAAF01932) |
| Specificity |
Synuclein-beta Polyclonal Antibody detects endogenous levels of Synuclein-beta protein. |
| Application Info |
WB: 1/500 - 1/2000
IHC: 1/100 - 1/300
IF: 1/200 - 1/1000
ELISA: 1/20000 |
| Immunogen |
The antiserum was produced against synthesized peptide derived from human Synuclein beta. |
| Dilution |
The optimal working dilution should be determined by the end user. |
| Uniprot ID |
Q16143 |
| Protein Name |
Beta-synuclein |
| Protein Accession # |
NP_001001502.1 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
SNCB |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | human brain tissue
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synuclein beta Antibody. The picture on the right is treated with the synthesized peptide. |
| | Image 2 | A549 cells
 | Immunofluorescence analysis of A549 cells, using Synuclein beta Antibody. The picture on the right is treated with the synthesized peptide. |
| | Image 3 | HeLa cells
 | Western blot analysis of extracts from HeLa cells, using Synuclein beta Antibody. The lane on the right is treated with the synthesized peptide. |
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