| Product Number |
OAAD00274 |
| Product Page |
www.avivasysbio.com/ep300-antibody-oaad00274.html |
| Name |
EP300 Antibody (OAAD00274) |
| Clone |
7D8A6 |
| Isotype |
IgG1 |
| NCBI Gene Id |
2033 |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Alias Symbols |
p300, KAT3B, MKHK2, RSTS2 |
| Reference |
1. J Biol Chem. 2007 Mar 30;282(13):9678-87.
2. Mol Cell Biol. 2008 Feb;28(4):1383-92. |
| Description of Target |
EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. |
| Reconstitution and Storage |
Store at 4C, for long term storage, store at -20C. |
| Datasheets/Manuals |
Printable datasheet for EP300 Antibody (OAAD00274) - OAAD00274 |
| Application Info |
Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. |
| Immunogen |
Purified recombinant fragment of EP300 expressed in E. Coli. |
| Formulation |
Ascitic fluid containing 0.03% sodium azide. |
| Uniprot ID |
Q09472 |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Image 1 | EP300-His
 | western blot analysis using EP300 mouse mAb against truncated EP300-His recombinant protein (1). |
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