| Product Number |
OAAD00157 |
| Product Page |
www.avivasysbio.com/gelsolin-antibody-oaad00157.html |
| Name |
GELSOLIN Antibody (OAAD00157) |
| Clone |
GEL-42 |
| Isotype |
IgG1 |
| NCBI Gene Id |
2934 |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Concentration |
0.5 mg/ml |
| Alias Symbols |
ADF, AGEL |
| Product Format |
Liquid 50% slurry in PBS (pH 7.2) with 0.01 mg sodium azide preservative |
| Reference |
1. Kwiatkowski, D. J.; Ozelius, L.; Schuback, D.; Gusella, J.; Breakefield, X. O. : The gelsolin (GSN) cDNA clone, from 9q32-34, identifies BclI and StuI RFLPs. Nucleic Acids Res. 17: 4425 only, 1989.
2. Kwiatkowski, D. J.; Westbrook, C. A.; Bruns, G. A. P.; Morton, C. C. : Localization of gelsolin proximal to ABL on chromosome 9. Am. J. Hum. Genet. 42: 565-572, 1988.
3. Kwiatkowski, D. J.; Stossel, T. P.; Orkin, S. H.; Mole, J. E.; Colten, H. R.; Yin, H. L. : Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain.
Nature 323: 455-458, 1986. |
| Description of Target |
Gelsolin, a protein of leukocytes, platelets, and other cells, severs actin filaments in the presence of submicromolar calcium, thereby solating cytoplasmic actin gels. A gelsolin variant with 23 more N-terminal amino acids is a plasma component probably involved in the clearance of actin, the most abundant human protein, from the circulation. Gelsolin is located in 9q34. Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain.
This antibody is immobilized via covalent binding of primary amino groups to N-hydroxysuccinimide (NHS)-activated sepharose beads. It is useful for immunoprecipitation assays. |
| Reconstitution and Storage |
Store at 4°C for frequent use. |
| Datasheets/Manuals |
Printable datasheet for GELSOLIN Antibody (OAAD00157) - OAAD00157 |
| Specificity |
No cross reactivity with other proteins. |
| Immunogen |
Human plasma gelsolin. |
| Formulation |
Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative. |
| Uniprot ID |
P06396 |
| Protein Name |
Gelsolin |
| Purification |
Purified by the goat anti-mouse IgG Affinity chromatography. |
| Gene Symbol |
GSN |
| Predicted Species Reactivity |
Human, Rabbit, Bovine |
| Application |
IP |
| Image 1 | |
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