| Product Number |
OAAD00121 |
| Product Page |
www.avivasysbio.com/atp2a1-antibody-oaad00121.html |
| Name |
ATP2A1 Antibody (OAAD00121) |
| Clone |
CAP-6 |
| Isotype |
IgG2a |
| NCBI Gene Id |
487 |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Gene Full Name |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| Alias Symbols |
ATP2A, SERCA1 |
| Reference |
Street, V. A.; McKee-Johnson, J. W.; Fonseca, R. C.; Tempel, B. L.; Noben-Trauth, K. : Mutations in a plasma membrane Ca(2+)-ATPase gene cause deafness in deafwaddler mice. Nature Genet. 19: 390-394, 1998. |
| Description of Target |
The Ca(2+)-ATPases are a family of plasma membrane pumps encoded by at least 4 genes: ATP2B1 on chromosome 12q21; ATP2B2; ATP2B3 on Xq28; and ATP2B4 on 1q25. The proteins share 84% amino acid sequence identity and 76% nucleic acid sequence homology. The function of calcium-transporting ATPase found in different membranes is to lower cytoplasmic Ca(2+) concentration by pumping Ca(2+) to luminal or extracellular spaces. Mutations in a plasma membrane Ca(2+)-ATPase gene cause deafness in deafwaddler mice. |
| Reconstitution and Storage |
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time. |
| Datasheets/Manuals |
Printable datasheet for anti-ATP2A1 (OAAD00121) antibody |
| Specificity |
Human, rat, rabbit. chicken.
No cross reactivity with other proteins. |
| Application Info |
Western blot At 4ug/ml with the appropriate system to detect Ca2+ ATPase in cells and tissues.
Immunohistochemistry(P) At 8ug/ml to detect ATPase in formalin fixed and paraffin embedded tissues.
Other applications have not been tested.
Optimal dilutions should be determined by end user. |
| Immunogen |
Human erythrocyte Ca2+-ATPase. |
| Formulation |
Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative. |
| Storage Buffer |
1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml. |
| Uniprot ID |
O14983 |
| Protein Name |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| Protein Accession # |
NP_001273004.1; NP_004311.1; NP_775293.1 |
| Purification |
Purified by the goat anti-mouse IgG Affinity chromatography. |
| Nucleotide Accession # |
NM_001286075.1; NM_004320.4; NM_173201.3 |
| Gene Symbol |
ATP2A1 |
| Predicted Species Reactivity |
Human, Rat, Rabbit Chicken |
| Application |
WB, IHC, IP |
| Image 1 | |
|
