Product Number |
OAAB18261 |
Product Page |
www.avivasysbio.com/mapk6-antibody-phospho-s189-oaab18261.html |
Name |
MAPK6 Antibody (Phospho-Ser189) (OAAB18261) |
Molecular Weight |
83 kDa, 82 kDa |
Isotype |
Rabbit Ig |
NCBI Gene Id |
5597 |
Host |
Rabbit |
Clonality |
Polyclonal |
Alias Symbols |
ERK3, PRKM6, p97MAPK, HsT17250 |
Product Format |
Liquid. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Reference |
Rai, R., et al., Oral Oncol. 40(7):705-712 (2004). Coulombe, P., et al., Mol. Cell. Biol. 24(14):6140-6150 (2004). Coulombe, P., et al., Mol. Cell. Biol. 23(13):4542-4558 (2003). Julien, C., et al., J. Biol. Chem. 278(43):42615-42624 (2003). Robinson, M.J., et al., J. Biol. Chem. 277(7):5094-5100 (2002). |
Description of Target |
ERK3 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB18261 |
Application Info |
IHC-P: 1:50~100 |
Immunogen |
This Phospho-ERK3-S189 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S189 of human ERK3. |
Uniprot ID |
Q16659, P27704, Q61532, Q5F3W3 |
Protein Accession # |
NP_002739.1 |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Gene Symbol |
MAPK6 |
Predicted Species Reactivity |
Mouse, Rat |
Application |
IHC |
Predicted Homology Based on Immunogen Sequence |
Mouse; Rat |
Image 1 | Human cancer tissue
| Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. Dilution: 1:50~100 |
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