Product Number |
OAAB17410 |
Product Page |
www.avivasysbio.com/trpm7-chak1-antibody-n-terminal-region-oaab17410.html |
Name |
TRPM7 Antibody - N-terminal region (OAAB17410) |
Molecular Weight |
213 kDa |
Isotype |
Ig |
NCBI Gene Id |
54822 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
2 mg/ml |
Alias Symbols |
CHAK, CHAK1, ALSPDC, LTRPC7, LTrpC-7, TRP-PLIK |
Product Format |
Liquid PBS with 0.09% (W/V) sodium azide. |
Description of Target |
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants. |
Reconstitution and Storage |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB17410 |
Additional Information |
Cellular Location: Membrane; Multi-pass membrane protein. |
Application Info |
IHC-P: 1:50~100 |
Immunogen |
This TRPM7 (CHAK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human TRPM7 (CHAK1). |
Uniprot ID |
Q96QT4 |
Protein Name |
Transient receptor potential cation channel subfamily M member 7 |
Protein Accession # |
NP_060142.3 |
Purification |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Gene Symbol |
TRPM7 |
Predicted Species Reactivity |
Human |
Application |
IHC-P, ELISA |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | breast carcinoma
| Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
| Image 2 | K562
| The anti-CHAK1 Pab (Cat. # OAAB17410) is used in Western blot to detect CHAK1 in K562 cell lysate. |
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