| Product Number |
OAAB17329 |
| Product Page |
www.avivasysbio.com/prkx-antibody-c-terminal-region-oaab17329.html |
| Name |
PRKX Antibody - C-terminal region (OAAB17329) |
| Molecular Weight |
40896 Da |
| Isotype |
Ig |
| NCBI Gene Id |
5613 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
PKX1 |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Description of Target |
Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB17329 |
| Additional Information |
Precautions: PRKX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation |
| Application Info |
IHC-P: 1:10~50 |
| Immunogen |
This PRKX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-343 amino acids from the C-terminal region of human PRKX. |
| Additional Information |
Cellular Location: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation
Tissue Location: Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982 |
| Uniprot ID |
P51817 |
| Protein Name |
cAMP-dependent protein kinase catalytic subunit PRKX |
| Protein Accession # |
NP_005035.1 |
| Gene Symbol |
PRKX |
| Predicted Species Reactivity |
Human, Mouse |
| Application |
IHC |
| Predicted Homology Based on Immunogen Sequence |
Human; Mouse |
| Image 1 | Human lung carcinoma
 | Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PRKX antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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