MST3 Antibody - C-terminal region (OAAB17312)

Data Sheet
 
Product Number OAAB17312
Product Page www.avivasysbio.com/mst3-antibody-c-terminal-region-oaab17312.html
Name MST3 Antibody - C-terminal region (OAAB17312)
Molecular Weight 49308 Da
Isotype Ig
NCBI Gene Id 8428
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols MST3, STK3, MST3B, STE20, HEL-S-95
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Description of Target Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB17312
Additional Information Precautions: MST3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve
Application Info WB: 1:1000
IHC-P: 1:50~100
Immunogen This MST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the C-terminal region of human MST3.
Additional Information Cellular Location: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane
Tissue Location: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex
Uniprot ID Q9Y6E0
Protein Name Serine/threonine-protein kinase 24
Sample Type Confirmation

STK24 is strongly supported by BioGPS gene expression data to be expressed in HepG2

Protein Accession # NP_001027467.2
Gene Symbol STK24
Predicted Species Reactivity Human
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Human
Image 1
hepatocarcinoma
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Image 2
HepG2
Western blot analysis of MST3 Antibody (C-term) (Cat.# OAAB17312) in HepG2 cell line lysates (35ug/lane). MST3 (arrow) was detected using the purified Pab.

STK24 is strongly supported by BioGPS gene expression data to be expressed in HepG2

 

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