ACVRL1 Antibody - N-terminal region (OAAB17261)

• Product Number: OAAB17261
• Name: ACVRL1 Antibody - N-terminal region (OAAB17261)
• Molecular Weight: 56124 Da
• Isotype: Ig
• NCBI Gene Id: 94
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: HHT, ALK1, HHT2, ORW2, SKR3, ALK-1, TSR-I, ACVRLK1
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Precautions: ACVRL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Additional Information: Function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well
• Application Info: WB: 1:1000
  FC: 1:10~50
  IHC-P: 1:50~100
• Immunogen: This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-68 amino acids from the N-terminal region of human ACVRL1.
• Additional Information: Cellular Location: Membrane; Single-pass type I membrane protein
• Uniprot ID: P37023
• Protein Name: Serine/threonine-protein kinase receptor R3
• Sample Type Confirmation:

  ACVRL1 is strongly supported by BioGPS gene expression data to be expressed in HEK293

• Protein Accession #: NP_000011.2
• Gene Symbol: ACVRL1
• Predicted Species Reactivity: Human, Mouse
• Application: WB, FC
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Image 1: 293
  
  Western blot analysis of ACVRL1 (arrow) using rabbit polyclonal ACVRL1 Antibody (N-term) (Cat. # OAAB17261). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVRL1 gene (Lane 2) (Origene Technologies).

  ACVRL1 is strongly supported by BioGPS gene expression data to be expressed in HEK293

• Image 2: Mouse Heart
  
  Western blot of ACVRL1 Pab (Cat. # OAAB17261). TOP LEFT: Mouse heart tissue lysate.
• Image 3: HepG2
  
  Flow cytometric analysis of HepG2 cells using ACVRL1 Antibody (N-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.