ACVR1B Antibody - middle region (OAAB17252)

Data Sheet
 
Product Number OAAB17252
Product Page www.avivasysbio.com/activin-a-receptor-type-ib-acvr1b-antibody-center-region-oaab17252.html
Name ACVR1B Antibody - middle region (OAAB17252)
Molecular Weight 56807 Da
Isotype Ig
NCBI Gene Id 91
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols ALK4, SKR2, ACTRIB, ACVRLK4
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB17252
Additional Information Precautions: Activin A Receptor Type IB (ACVR1B) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2
Application Info FC: 1:10~50
WB: 1:1000
Immunogen This Activin A Receptor Type IB (ACVR1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human Activin A Receptor Type IB (ACVR1B).
Additional Information Cellular Location: Cell membrane; Single-pass type I membrane protein (By similarity)
Tissue Location: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver
Uniprot ID P36896
Protein Name Activin receptor type-1B
Protein Accession # NP_004293.1
Gene Symbol ACVR1B
Predicted Species Reactivity Human, Mouse
Application FC
Predicted Homology Based on Immunogen Sequence Human; Mouse
Image 1
293
Flow cytometric analysis of 293 cells using Activin A Receptor Type IB (ACVR1B) Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram).
 

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