Product Number |
OAAB17208 |
Product Page |
www.avivasysbio.com/dok5-antibody-c-terminal-region-oaab17208.html |
Name |
DOK5 Antibody - C-terminal region (OAAB17208) |
Molecular Weight |
35464 Da |
Isotype |
Ig |
NCBI Gene Id |
55816 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
IRS6, IRS-6, C20orf180 |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Description of Target |
Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB17208 |
Additional Information |
Precautions: DOK5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation |
Application Info |
WB: 1:1000 IHC-P: 1:50~100 |
Immunogen |
This DOK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-306 amino acids from the C-terminal region of human DOK5. |
Additional Information |
Tissue Location: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes |
Uniprot ID |
Q9P104 |
Protein Name |
Docking protein 5 |
Protein Accession # |
NP_060901.2 |
Gene Symbol |
DOK5 |
Predicted Species Reactivity |
Human, Mouse |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Human; Mouse |
Image 1 | breast carcinoma
| Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
| Image 2 | Mouse Liver
| The anti-DOK5 C-term Pab (Cat. # OAAB17208) is used in Western blot to detect DOK5 in mouse liver tissue lysate. |
| Image 3 | 293
| Western blot analysis of DOK5 (arrow) using rabbit polyclonal DOK5 Antibody (L291) (Cat. # OAAB17208). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DOK5 gene. |
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