Insulin Receptor R Antibody - C-terminal region (OAAB17171)

• Product Number: OAAB17171
• Name: Insulin Receptor R Antibody - C-terminal region (OAAB17171)
• Molecular Weight: 143720 Da
• Isotype: Ig
• NCBI Gene Id: 3645
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: IRR
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Precautions: Insulin Receptor R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Additional Information: Function: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB
• Application Info: WB: 1:1000
  IHC-P: 1:50~100
• Immunogen: This Insulin Receptor R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1256-1287 amino acids from the C-terminal region of human Insulin Receptor R.
• Additional Information: Cellular Location: Membrane; Single-pass type I membrane protein
• Uniprot ID: P14616
• Protein Name: Insulin receptor-related protein
• Protein Accession #: NP_055030.1
• Gene Symbol: INSRR
• Predicted Species Reactivity: Human
• Application: WB, IHC
• Predicted Homology Based on Immunogen Sequence: Human
• Image 1: breast carcinoma
  
  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
• Image 2: A375
  
  Western blot analysis of anti-InsRR Pab (Cat. # OAAB17171) in A375 cell lysate. Lane A: preimmune, Lane B: purified antibody. InsRR (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.