| Product Number |
OAAB17122 |
| Product Page |
www.avivasysbio.com/axl-antibody-c-terminal-region-oaab17122.html |
| Name |
AXL Antibody - C-terminal region (OAAB17122) |
| Molecular Weight |
98337 |
| Isotype |
Ig |
| NCBI Gene Id |
558 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
AXL receptor tyrosine kinase |
| Description |
|
| Alias Symbols |
ARK;AXL oncogene;AXL transforming sequence/gene;JTK11;Tyro7;tyrosine-protein kinase receptor UFO;UFO. |
| Product Format |
Liquid PBS with 0.09% (W/V) sodium azide. |
| Description of Target |
Tyrosine-protein kinase receptor UFO, tyrosine-protein kinase receptor UFO isoform 1 precursor [Homo sapiens], tyrosine-protein kinase receptor UFO isoform 2 precursor [Homo sapiens] |
| Reconstitution and Storage |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for AXL Antibody (C-term) (OAAB17122) |
| Additional Information |
Cellular Location: Cell membrane; Single-pass type I membrane protein
Tissue Location: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue |
| Application Info |
WB: 1:1000
IHC-P: 1:50~100 |
| Immunogen |
This AXL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 863-894 amino acids from the C-terminal region of human AXL. |
| Uniprot ID |
https://www.uniprot.org/uniprot/P30530 |
| Protein Name |
NP_001690.2, NP_068713.2, P30530 |
| Publications |
Chemotherapy confers a conserved secondary tolerance to EGFR inhibition via AXL-mediated signaling bypass. Sci Rep. 11, 8016 (2021). 33850249 |
| Protein Accession # |
https://www.ncbi.nlm.nih.gov/protein/NP_001690.2,NP_068713.2 |
| Purification |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Gene Symbol |
AXL |
| Predicted Species Reactivity |
Human |
| Application |
Immunohistochemistry-Paraffin, Western blot |
| Image 1 | SKBR3
 | Western blot analysis of anti-AXL C-term Pab (Cat. # OAAB17122) in SKBR3 cell lysate. AXL (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. |
|
| Image 2 | breast carcinoma
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
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