CLK1 Antibody - N-terminal region (OAAB17091)

Data Sheet
 
Product Number OAAB17091
Product Page www.avivasysbio.com/clk1-antibody-n-terminal-region-oaab17091.html
Name CLK1 Antibody - N-terminal region (OAAB17091)
Molecular Weight 57291 Da
Isotype Ig
NCBI Gene Id 1195
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols CLK, STY, CLK/STY
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Description of Target This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB17091
Additional Information Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Cellular Location: Nucleus.
Tissue Location: Endothelial cells.
Application Info WB: 1:1000
Immunogen This CLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the N-terminal region of human CLK1.
Intended Use For research use only and not for use in diagnostic or therapeutic procedures.
Uniprot ID P49759
Protein Name Dual specificity protein kinase CLK1
Protein Accession # NP_001155879.1
Purification This antibody is purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Gene Symbol CLK1
Predicted Species Reactivity Human
Application WB
Predicted Homology Based on Immunogen Sequence Human
Image 1
Y79
Western blot analysis of anti-hCLK1-C84 Pab (Cat. # OAAB17091) in Y79 cell line lysate. hCLK1-C84(arrow) was detected using the purified Pab.
 

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