Product Number |
OAAB17091 |
Product Page |
www.avivasysbio.com/clk1-antibody-n-terminal-region-oaab17091.html |
Name |
CLK1 Antibody - N-terminal region (OAAB17091) |
Molecular Weight |
57291 Da |
Isotype |
Ig |
NCBI Gene Id |
1195 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
CLK, STY, CLK/STY |
Product Format |
Liquid. PBS with 0.09% (W/V) sodium azide. |
Description of Target |
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB17091 |
Additional Information |
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Cellular Location: Nucleus.
Tissue Location: Endothelial cells. |
Application Info |
WB: 1:1000 |
Immunogen |
This CLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the N-terminal region of human CLK1. |
Intended Use |
For research use only and not for use in diagnostic or therapeutic procedures. |
Uniprot ID |
P49759 |
Protein Name |
Dual specificity protein kinase CLK1 |
Protein Accession # |
NP_001155879.1 |
Purification |
This antibody is purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Gene Symbol |
CLK1 |
Predicted Species Reactivity |
Human |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | Y79
| Western blot analysis of anti-hCLK1-C84 Pab (Cat. # OAAB17091) in Y79 cell line lysate. hCLK1-C84(arrow) was detected using the purified Pab. |
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