DCAMKL1 Antibody - N-terminal region (OAAB16994)

Data Sheet
 
Product Number OAAB16994
Product Page www.avivasysbio.com/dcamkl1-antibody-n-terminal-region-oaab16994.html
Name DCAMKL1 Antibody - N-terminal region (OAAB16994)
Molecular Weight 82 kDa
Isotype Ig
NCBI Gene Id 9201
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols CL1, DCLK, CLICK1, DCDC3A, DCAMKL1
Product Format Liquid PBS with 0.09% (W/V) sodium azide.
Description of Target Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.
Reconstitution and Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16994
Additional Information Function: Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Tissue Location: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.
Application Info WB: 1:1000
Immunogen This DCAMKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DCAMKL1.
Uniprot ID O15075
Protein Name Serine/threonine-protein kinase DCLK1
Protein Accession # NP_001182344.1
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Gene Symbol DCLK1
Predicted Species Reactivity Human, Mouse
Application WB
Predicted Homology Based on Immunogen Sequence Human; Mouse
Image 1
T47D
DCAMKL1 Antibody (D13) (Cat. # OAAB16994) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow).
Image 2
Mouse Brain
Western blot analysis of DCAMKL1 Antibody (N-term) (Cat. # OAAB16994) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
 

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