ERN2 Antibody - C-terminal region (OAAB16895)

• Product Number: OAAB16895
• Name: ERN2 Antibody - C-terminal region (OAAB16895)
• Molecular Weight: 102 kDa
• Isotype: Ig
• NCBI Gene Id: 10595
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Varies by lot. See vial for concentration.
• Alias Symbols: IRE1b, IRE2p, hIRE2p, IRE1-BETA
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Description of Target: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Application Info: WB: 1:1000
• Immunogen: This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-810 amino acids from the C-terminal region of human ERN2.
• Additional Information: Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
• Uniprot ID: Q76MJ5
• Protein Name: Serine/threonine-protein kinase/endoribonuclease IRE2
• Protein Accession #: NP_150296.3
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Gene Symbol: ERN2
• Predicted Species Reactivity: Human
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Human
• Image 1: Mouse Liver
  
  The anti-ERN2 Pab (Cat. # OAAB16895) is used in Western blot to detect ERN2 in mouse liver tissue lysate