TAOK1 Antibody - middle region (OAAB16843)

Data Sheet
 
Product Number OAAB16843
Product Page www.avivasysbio.com/taok1-antibody-center-region-oaab16843.html
Name TAOK1 Antibody - middle region (OAAB16843)
Molecular Weight 116070 Da
Isotype Ig
NCBI Gene Id 57551
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols PSK2, TAO1, KFC-B, MARKK, PSK-2, hKFC-B, hTAOK1, MAP3K16
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Description of Target Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16843
Additional Information Precautions: TAOK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade
Application Info WB: 1:1000
Immunogen This TAOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 620-650 amino acids from the Central region of human TAOK1.
Additional Information Cellular Location: Cytoplasm.
Tissue Location: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle
Uniprot ID Q7L7X3
Protein Name Serine/threonine-protein kinase TAO1
Protein Accession # NP_065842.1
Gene Symbol TAOK1
Predicted Species Reactivity Human
Application WB
Predicted Homology Based on Immunogen Sequence Human
Image 1
Mouse Brain
Western blot analysis of anti-TAOK1 Pab (OAAB16843) in mouse brain tissue lysate (35ug/lane). TAOK1(arrow) was detected using the purified Pab (1:60 dilution).
 

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