Product Number |
OAAB16843 |
Product Page |
www.avivasysbio.com/taok1-antibody-center-region-oaab16843.html |
Name |
TAOK1 Antibody - middle region (OAAB16843) |
Molecular Weight |
116070 Da |
Isotype |
Ig |
NCBI Gene Id |
57551 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
PSK2, TAO1, KFC-B, MARKK, PSK-2, hKFC-B, hTAOK1, MAP3K16 |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Description of Target |
Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16843 |
Additional Information |
Precautions: TAOK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade |
Application Info |
WB: 1:1000 |
Immunogen |
This TAOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 620-650 amino acids from the Central region of human TAOK1. |
Additional Information |
Cellular Location: Cytoplasm. Tissue Location: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle |
Uniprot ID |
Q7L7X3 |
Protein Name |
Serine/threonine-protein kinase TAO1 |
Protein Accession # |
NP_065842.1 |
Gene Symbol |
TAOK1 |
Predicted Species Reactivity |
Human |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | Mouse Brain
| Western blot analysis of anti-TAOK1 Pab (OAAB16843) in mouse brain tissue lysate (35ug/lane). TAOK1(arrow) was detected using the purified Pab (1:60 dilution). |
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