PRKAB2 Antibody - N-terminal region (OAAB16786)

Data Sheet
 
Product Number OAAB16786
Product Page www.avivasysbio.com/ampk-beta2-prkab2-antibody-n-terminal-region-oaab16786.html
Name PRKAB2 Antibody - N-terminal region (OAAB16786)
Molecular Weight 30302 Da
Isotype Ig
NCBI Gene Id 5565
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols PRKAB2, 5'-AMP-activated protein kinase subunit beta-2
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16786
Additional Information Precautions: AMPK beta2 (PRKAB2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)
Application Info WB: 1:1000
Immunogen This AMPK beta2 (PRKAB2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human AMPK beta2 (PRKAB2).
Uniprot ID O43741
Protein Name 5'-AMP-activated protein kinase subunit beta-2
Protein Accession # NP_005390.1
Gene Symbol PRKAB2
Predicted Species Reactivity Human, Mouse
Application WB
Predicted Homology Based on Immunogen Sequence Human; Mouse
Image 1
Mouse Kidney
PRKAB2 Antibody (A18) (Cat. # OAAB16786) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the PRKAB2 antibody detected the PRKAB2 protein (arrow).
Image 2
A375
PRKAB2 Antibody (A18) (Cat. # OAAB16786) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PRKAB2 antibody detected the PRKAB2 protein (arrow).
 

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