Kallikrein 8 Antibody - middle region (OAAB16649)

• Product Number: OAAB16649
• Name: Kallikrein 8 Antibody - middle region (OAAB16649)
• Molecular Weight: 28048 Da
• Isotype: Ig
• NCBI Gene Id: 11202
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: NP, HNP, NRPN, PRSS19, TADG14
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Precautions: Kallikrein 8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
• Additional Information: Function: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury
• Application Info: WB: 1:1000
  IHC-P: 1:10~50
• Immunogen: This Kallikrein 8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human Kallikrein 8.
• Additional Information: Cellular Location: Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes
  Tissue Location: Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus Isoform 1 and isoform 2 are found in fetal brain and placenta Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpresse
• Uniprot ID: O60259
• Protein Name: Kallikrein-8
• Protein Accession #: NP_009127.1
• Gene Symbol: KLK8
• Predicted Species Reactivity: Mouse
• Application: WB, IHC
• Predicted Homology Based on Immunogen Sequence: Mouse
• Image 1: Mouse Kidney
  
  KLK8 Antibody (G158) (Cat. # OAAB16649) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the KLK8 antibody detected the KLK8 protein (arrow).
• Image 2: Human Pancreas
  
  Kallikrein 8(KLK8) Antibody (Center) (Cat. # OAAB16649) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 8(KLK8) Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.