Kallikrein 7 Antibody - center region (OAAB16647)

Data Sheet
 
Product Number OAAB16647
Product Page www.avivasysbio.com/kallikrein-7-antibody-center-region-oaab16647.html
Name Kallikrein 7 Antibody - center region (OAAB16647)
Molecular Weight 27525 Da
Isotype Ig
NCBI Gene Id 5650
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols hK7, SCCE, PRSS6
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16647
Additional Information Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-l-Cys-7', '16-Tyr-l-Leu-17', '25-Phe-l-Tyr-26' and '26-Tyr-l-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines
Application Info WB: 1:2000
WB: 1:1000
IHC-P: 1:10~50
Immunogen This Kallikrein 7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-97 amino acids from the Central region of human Kallikrein 7.
Additional Information Cellular Location: Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front
Tissue Location: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level)
Intended Use Kallikrein 7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Uniprot ID P49862
Protein Name Kallikrein-7
Protein Accession # NP_001193982.1
Gene Symbol KLK7
Predicted Species Reactivity Human
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Human
Image 1
MDA-MB231
KLK7 Antibody (S82) (Cat. # OAAB16647) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the KLK7 antibody detected the KLK7 protein (arrow).
Image 2
Human Skin
Kallikrein 7(KLK7) Antibody (Center) (Cat. # OAAB16647) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 7(KLK7) Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
 

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