| Product Number |
OAAB16593 |
| Product Page |
www.avivasysbio.com/sost-antibody-center-region-oaab16593.html |
| Name |
SOST Antibody - middle region (OAAB16593) |
| Molecular Weight |
24031 Da |
| Isotype |
Ig |
| NCBI Gene Id |
50964 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
CDD, VBCH, DAND6, SOST1 |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Description of Target |
Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16593 |
| Additional Information |
Precautions: SOST Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation |
| Application Info |
WB: 1:1000
IHC-P: 1:10~50 |
| Immunogen |
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human SOST. |
| Additional Information |
Cellular Location: Secreted, extracellular space, extracellular matrix
Tissue Location: Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level) |
| Uniprot ID |
Q9BQB4 |
| Protein Name |
Sclerostin |
| Protein Accession # |
NP_079513.1 |
| Gene Symbol |
SOST |
| Predicted Species Reactivity |
Human |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | Mouse Lung
 | Western blot analysis of SOST Antibody (Center) (Cat. # OAAB16593) in mouse lung tissue lysates (35ug/lane). SOST (arrow) was detected using the purified Pab. |
| | Image 2 | Human hepatocarcinoma
 | Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center) (Cat.# OAAB16593), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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