MAGEB2 Antibody - N-terminal region (OAAB16520)

Data Sheet
 
Product Number OAAB16520
Product Page www.avivasysbio.com/mageb2-antibody-n-terminal-region-oaab16520.html
Name MAGEB2 Antibody - N-terminal region (OAAB16520)
Molecular Weight 35 kDa
Isotype Ig
NCBI Gene Id 4113
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols DAM6, CT3.2, MAGE-XP-2
Product Format Liquid PBS with 0.09% (W/V) sodium azide.
Description of Target MAGEB2 is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16520
Additional Information Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Tissue Location: Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
Application Info WB: 1:1000
IHC-P: 1:50~100
Immunogen This MAGEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human MAGEB2.
Uniprot ID O15479
Protein Name Melanoma-associated antigen B2
Protein Accession # NP_002355.2
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Gene Symbol MAGEB2
Predicted Species Reactivity Human
Application WB, IHC-P
Image 1
293
Western blot analysis of MAGEB2(arrow) using rabbit polyclonal MAGEB2 Antibody (Cat.# OAAB16520). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAGEB2 gene (Lane 2) (Origene Technologies).
Image 2
breast carcinoma
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
 

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