Product Number |
OAAB16448 |
Product Page |
www.avivasysbio.com/tsc2-antibody-phospho-s1388-oaab16448.html |
Name |
TSC2 Antibody (Phospho-Ser1388) (OAAB16448) |
Molecular Weight |
200608 Da |
Isotype |
Ig |
NCBI Gene Id |
7249 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
LAM, TSC4, PPP1R160 |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16448 |
Additional Information |
Precautions: TSC2 Antibody (Phospho S1388) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors |
Application Info |
DB: 1:500 |
Immunogen |
This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1388 of human TSC2. |
Additional Information |
Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes Tissue Location: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta |
Uniprot ID |
P49815 |
Protein Name |
Tuberin |
Protein Accession # |
NP_000539.2 |
Gene Symbol |
TSC2 |
Predicted Species Reactivity |
Human |
Application |
DB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of TSC2 Antibody (Phospho S1388) Phospho-specific Pab (Cat. # OAAB16448) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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