| Product Number |
OAAB16442 |
| Product Page |
www.avivasysbio.com/tsc1-antibody-phospho-t390-oaab16442.html |
| Name |
TSC1 Antibody (Phospho-Thr390) (OAAB16442) |
| Molecular Weight |
129767 Da |
| Isotype |
Ig |
| NCBI Gene Id |
7248 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
LAM, TSC |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16442 |
| Additional Information |
Precautions: TSC1 Antibody (Phospho T390) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling |
| Application Info |
DB: 1:500 |
| Immunogen |
This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T390 of human TSC1. |
| Additional Information |
Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells |
| Uniprot ID |
Q92574 |
| Protein Name |
Hamartin |
| Protein Accession # |
NP_000359.1 |
| Gene Symbol |
TSC1 |
| Predicted Species Reactivity |
Human |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of TSC1 Antibody (Phospho T390) Phospho-specific Pab (Cat. # OAAB16442) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
|
|
