TSC1 Antibody (Phospho-Ser1080) (OAAB16441)

Data Sheet
Product Number OAAB16441
Product Page www.avivasysbio.com/tsc1-antibody-phospho-s1080-oaab16441.html
Name TSC1 Antibody (Phospho-Ser1080) (OAAB16441)
Molecular Weight 129767 Da
Isotype Ig
NCBI Gene Id 7248
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols LAM, TSC
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16441
Additional Information Precautions: TSC1 Antibody (Phospho S1080) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling
Application Info DB: 1:500
Immunogen This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1080 of human TSC1.
Additional Information Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells
Uniprot ID Q92574
Protein Name Hamartin
Protein Accession # NP_000359.1
Gene Symbol TSC1
Predicted Species Reactivity Human
Application DB, ELISA, IHC, WB
Predicted Homology Based on Immunogen Sequence Human
Image 1
Phospho-peptide, non-phospho-peptide
Dot blot analysis of TSC1 Antibody (Phospho S1080) Phospho-specific Pab (Cat. # OAAB16441) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

6370 Nancy Ridge Dr., Suite 104, San Diego, CA 92121 USA | Tel: (858)552-6979 | info@avivasysbio.com