| Product Number |
OAAB16424 |
| Product Page |
www.avivasysbio.com/mouse-p21cip1-antibody-phospho-s125-oaab16424.html |
| Name |
p21Cip1 Antibody (Phospho-Ser125) (OAAB16424) |
| Molecular Weight |
17785 Da |
| Isotype |
Ig |
| NCBI Gene Id |
12575 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
CI, P2, SD, CAP, CDK, P21, Waf, mda, CDKI, CIP1, Cdkn, SDI1, Waf1, mda6, p21C, p21W, CAP20, Cdkn1, p21WAF, p21Cip1 |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16424 |
| Additional Information |
Precautions: Mouse p21Cip1 Antibody (Phospho S125) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity) |
| Application Info |
DB: 1:500 |
| Immunogen |
This mouse p21Cip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S125 of mouse p21Cip1. |
| Additional Information |
Cellular Location: Cytoplasm (By similarity). Nucleus. |
| Uniprot ID |
P39689 |
| Protein Name |
Cyclin-dependent kinase inhibitor 1 |
| Protein Accession # |
NP_001104569.1 |
| Gene Symbol |
Cdkn1a |
| Predicted Species Reactivity |
Mouse |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Mouse |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of Mouse p21Cip1 Antibody (Phospho S125) Phospho-specific Pab (Cat. # OAAB16424) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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