CCND3 Antibody (Phospho-Thr283) (OAAB16419)

Data Sheet
 
Product Number OAAB16419
Product Page www.avivasysbio.com/ccnd3-antibody-phospho-t283-oaab16419.html
Name CCND3 Antibody (Phospho-Thr283) (OAAB16419)
Molecular Weight 32520 Da
Isotype Ig
NCBI Gene Id 896
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols CCND3, G1/S-specific cyclin-D3
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16419
Additional Information Precautions: CCND3 Antibody (Phospho T283) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex
Application Info DB: 1:500
Immunogen This CCND3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T283 of human CCND3.
Additional Information Cellular Location: Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity)
Uniprot ID P30281
Protein Name G1/S-specific cyclin-D3
Protein Accession # NP_001129489.1
Gene Symbol CCND3
Predicted Species Reactivity Human
Application DB
Predicted Homology Based on Immunogen Sequence Human
Image 1
Phospho-peptide, non-phospho-peptide
Dot blot analysis of CCND3 Antibody (Phospho T283) Phospho-specific Pab (Cat. # OAAB16419) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
 

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