Product Number |
OAAB16419 |
Product Page |
www.avivasysbio.com/ccnd3-antibody-phospho-t283-oaab16419.html |
Name |
CCND3 Antibody (Phospho-Thr283) (OAAB16419) |
Molecular Weight |
32520 Da |
Isotype |
Ig |
NCBI Gene Id |
896 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
CCND3, G1/S-specific cyclin-D3 |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16419 |
Additional Information |
Precautions: CCND3 Antibody (Phospho T283) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex |
Application Info |
DB: 1:500 |
Immunogen |
This CCND3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T283 of human CCND3. |
Additional Information |
Cellular Location: Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity) |
Uniprot ID |
P30281 |
Protein Name |
G1/S-specific cyclin-D3 |
Protein Accession # |
NP_001129489.1 |
Gene Symbol |
CCND3 |
Predicted Species Reactivity |
Human |
Application |
DB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of CCND3 Antibody (Phospho T283) Phospho-specific Pab (Cat. # OAAB16419) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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