TSC1 Antibody (Phospho-Ser511) (OAAB16411)

Data Sheet
 
Product Number OAAB16411
Product Page www.avivasysbio.com/tsc1-phospho-s511-antibody-oaab16411.html
Name TSC1 Antibody (Phospho-Ser511) (OAAB16411)
Molecular Weight 130 kDa
Isotype Ig
NCBI Gene Id 7248
Host Rabbit
Clonality Polyclonal
Concentration 0.36 mg/ml
Alias Symbols LAM, TSC
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Description of Target This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16411
Application Info DB: 1:500
Immunogen This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S511 of human TSC1.
Additional Information Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
Uniprot ID Q92574
Protein Name Hamartin
Protein Accession # NP_000359.1
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Gene Symbol TSC1
Predicted Species Reactivity Human
Application DB
Image 1
Phospho-peptide, non-phospho-peptide
Dot blot analysis of TSC1 Antibody (Phospho S511) Phospho-specific Pab (Cat. # OAAB16411) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
 

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

AVIVA SYSTEMS BIOLOGY
10211 Pacific Mesa Blvd, Ste 401, San Diego, CA 92121 USA | Tel: (858)552-6979 | info@avivasysbio.com