Product Number |
OAAB16411 |
Product Page |
www.avivasysbio.com/tsc1-phospho-s511-antibody-oaab16411.html |
Name |
TSC1 Antibody (Phospho-Ser511) (OAAB16411) |
Molecular Weight |
130 kDa |
Isotype |
Ig |
NCBI Gene Id |
7248 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.36 mg/ml |
Alias Symbols |
LAM, TSC |
Product Format |
Liquid. PBS with 0.09% (W/V) sodium azide. |
Description of Target |
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16411 |
Application Info |
DB: 1:500 |
Immunogen |
This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S511 of human TSC1. |
Additional Information |
Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes Tissue Location: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells. |
Uniprot ID |
Q92574 |
Protein Name |
Hamartin |
Protein Accession # |
NP_000359.1 |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Gene Symbol |
TSC1 |
Predicted Species Reactivity |
Human |
Application |
DB |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of TSC1 Antibody (Phospho S511) Phospho-specific Pab (Cat. # OAAB16411) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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