| Product Number |
OAAB16409 |
| Product Page |
www.avivasysbio.com/rat-erbb2-antibody-phospho-t1168-oaab16409.html |
| Name |
ERBB2 Antibody (Phospho-Thr1168) (OAAB16409) |
| Molecular Weight |
138832 Da |
| Isotype |
Ig |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
Erbb2, Neu, Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD_antigen=CD340, Flags: Precursor |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16409 |
| Additional Information |
Precautions: Rat ERBB2 Antibody (Phospho T1168) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity) |
| Application Info |
DB: 1:500 |
| Immunogen |
This rat ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1168 of rat ERBB2. |
| Additional Information |
Cellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus |
| Uniprot ID |
P06494 |
| Protein Name |
Receptor tyrosine-protein kinase erbB-2 |
| Gene Symbol |
Erbb2 |
| Predicted Species Reactivity |
Rat |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Rat |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of rat ERBB2 Antibody (Phospho T1168) Phospho-specific Pab (Cat. # OAAB16409) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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