| Product Number |
OAAB16382 |
| Product Page |
www.avivasysbio.com/rat-tsc2-phospho-t1373-antibody-oaab16382.html |
| Name |
TSC2 Antibody (Phospho-Thr1373) (OAAB16382) |
| Molecular Weight |
201278 Da |
| Isotype |
Ig |
| NCBI Gene Id |
24855 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
Rc |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16382 |
| Additional Information |
Precautions: rat TSC2 (Phospho T1373) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth |
| Application Info |
DB: 1:500 |
| Immunogen |
This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2. |
| Additional Information |
Tissue Location: CNS, uterus, heart, skeletal muscle, kidney and spleen |
| Uniprot ID |
P49816 |
| Protein Name |
Tuberin |
| Protein Accession # |
NP_036812.2 |
| Gene Symbol |
Tsc2 |
| Predicted Species Reactivity |
Rat |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Rat |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of rat TSC2 Antibody (Phospho T1373) Phospho-specific Pab (Cat. # OAAB16382) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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