Product Number |
OAAB16380 |
Product Page |
www.avivasysbio.com/rat-tsc1-antibody-phospho-t417-oaab16380.html |
Name |
TSC1 Antibody (Phospho-Thr417) (OAAB16380) |
Molecular Weight |
129022 Da |
Isotype |
Ig |
NCBI Gene Id |
60445 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
Tsc1, Hamartin, Tuberous sclerosis 1 protein homolog |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16380 |
Additional Information |
Precautions: Rat TSC1 Antibody (Phospho T417) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity) |
Application Info |
DB: 1:500 |
Immunogen |
This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T417 of rat TSC1. |
Additional Information |
Cellular Location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=At steady state found in association with membranes (By similarity) Tissue Location: Highly expressed in brain, spleen and kidney, followed by liver and heart |
Uniprot ID |
Q9Z136 |
Protein Name |
Hamartin |
Protein Accession # |
NP_068626.1 |
Gene Symbol |
Tsc1 |
Predicted Species Reactivity |
Rat |
Application |
DB |
Predicted Homology Based on Immunogen Sequence |
Rat |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of rat TSC1 Antibody (Phospho T417) Phospho-specific Pab (Cat. # OAAB16380) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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