Product Number |
OAAB16374 |
Product Page |
www.avivasysbio.com/mouse-tsc2-phospho-s1365-antibody-oaab16374.html |
Name |
TSC2 Antibody (Phospho-Ser1365) (OAAB16374) |
Molecular Weight |
202071 Da |
Isotype |
Ig |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
Tsc2, Tuberin, Tuberous sclerosis 2 protein homolog |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16374 |
Additional Information |
Precautions: mouse TSC2 (Phospho S1365) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity) |
Application Info |
DB: 1:500 |
Immunogen |
This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1365 of mouse TSC2. |
Additional Information |
Cellular Location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=At steady state found in association with membranes (By similarity) Tissue Location: Widely expressed. |
Uniprot ID |
Q61037 |
Protein Name |
Tuberin |
Gene Symbol |
Tsc2 |
Predicted Species Reactivity |
Mouse |
Application |
DB |
Predicted Homology Based on Immunogen Sequence |
Mouse |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of mouse TSC2 Antibody (Phospho S1365) Phospho-specific Pab (Cat. # OAAB16374) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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