TSC2 Antibody (Phospho-Ser1365) (OAAB16374)

Data Sheet
 
Product Number OAAB16374
Product Page www.avivasysbio.com/mouse-tsc2-phospho-s1365-antibody-oaab16374.html
Name TSC2 Antibody (Phospho-Ser1365) (OAAB16374)
Molecular Weight 202071 Da
Isotype Ig
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols Tsc2, Tuberin, Tuberous sclerosis 2 protein homolog
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16374
Additional Information Precautions: mouse TSC2 (Phospho S1365) is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity)
Application Info DB: 1:500
Immunogen This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1365 of mouse TSC2.
Additional Information Cellular Location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=At steady state found in association with membranes (By similarity)
Tissue Location: Widely expressed.
Uniprot ID Q61037
Protein Name Tuberin
Gene Symbol Tsc2
Predicted Species Reactivity Mouse
Application DB
Predicted Homology Based on Immunogen Sequence Mouse
Image 1
Phospho-peptide, non-phospho-peptide
Dot blot analysis of mouse TSC2 Antibody (Phospho S1365) Phospho-specific Pab (Cat. # OAAB16374) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
 

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