| Product Number |
OAAB16355 |
| Product Page |
www.avivasysbio.com/ulk2-phospho-s323-antibody-oaab16355.html |
| Name |
ULK2 Antibody (Phospho-Ser323) (OAAB16355) |
| Molecular Weight |
112694 Da |
| Isotype |
Ig |
| NCBI Gene Id |
9706 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
ATG1B, Unc51.2 |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16355 |
| Additional Information |
Precautions: ULK2 (Phospho S323) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons |
| Application Info |
DB: 1:500 |
| Immunogen |
This ULK2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S323 of human ULK2. |
| Additional Information |
Cellular Location: Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane |
| Uniprot ID |
Q8IYT8 |
| Protein Name |
Serine/threonine-protein kinase ULK2 |
| Protein Accession # |
NP_001136082.1 |
| Gene Symbol |
ULK2 |
| Predicted Species Reactivity |
Human |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of ULK2 Antibody (Phospho S323) Phospho-specific Pab (Cat. # OAAB16355) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
|
|
