| Product Number |
OAAB16326 |
| Product Page |
www.avivasysbio.com/parp1-antibody-phospho-s373-oaab16326.html |
| Name |
PARP1 Antibody (Phospho-Ser373) (OAAB16326) |
| Molecular Weight |
112660 Da |
| Isotype |
Ig |
| NCBI Gene Id |
25591 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
ARTD1, Adprt, Parp-1 |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16326 |
| Additional Information |
Precautions: Phospho-rat PARP1-S373 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly (ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity) |
| Application Info |
DB: 1:500 |
| Immunogen |
This rat PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S373 of rat PARP1. |
| Additional Information |
Cellular Location: Nucleus (By similarity). Nucleus, nucleolus (By similarity) |
| Uniprot ID |
P27008 |
| Protein Name |
Poly [ADP-ribose] polymerase 1 |
| Protein Accession # |
NP_037195.1 |
| Gene Symbol |
Parp1 |
| Predicted Species Reactivity |
Rat |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Rat |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of Phospho-rat PARP1-S373 Antibody Phospho-specific Pab (Cat. # OAAB16326) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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